Our Stolen Futurea book by Theo Colborn, Dianne Dumanoski, and John Peterson Myers


Emerging studies examining links between
endocrine disrupting contaminants and cancer

Newbold, RR, EP Banks, B Bullock, and WN Jefferson 2001. Uterine adenocarcinoma in mice treated neonatally with genistein. Cancer Research 61: 4325-4328.

Newbold et al. report that when neonatal mice are exposed to genistein—a phytoestrogen present in soy—later in life they develop uterine cancer of the same form caused by diethylstilbestrol (DES). The levels of genistein used in these experiments are comparable to those found in infant formula based on soy. More...

Weir, HK, LD Marrett, N Kreiger, GA Darlington and L Sugar. 2000. Pre-natal and peri-natal exposures and risk of testicular germ cell cancers. International Journal of Cancer 87:438-443.

This case control study found a positive association between exogenous estrogens (DES and premarin) and risk of testicular cancer. "Not only does exposure to elevated levels (exogenous hormone use, pre-term birth, and first birth among young mothers) increase risk, but also exposure to relatively lower levels (heavy cigarette consumption, and perhaps, bleeding and threatened miscarriage) may decrease cancer risk." More...


  Porta, M, N Malats, M Jariod, JO Grimalt, J Rifa, A Carrato, L Guarner, A Salas, M Santiago-Silva, JM Corominas, M Andreu, FX Real. 1999. Serum concentrations of organochlorine compounds and K-ras mutations in exocrine pancreatic cancer. The Lancet 354:2125-2129

The etiology of pancreatic cancer is poorly understood. Only one risk factor, smoking, has been established firmly. Epidemiological studies have hinted at a link to DDT exposure, but in general have found little or no association. The results presented by Porta et al. "suggest that organochlorine compounds such as p,p'-DDT, p,p'-DDE and some PCBs could play a part in the pathogenesis of exocrine pancreatic cancer through modulation of K-ras activation." The results, however, do not allow causal conclusions to be drawn. More...





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